SAT-102 Height Improvement with Recombinant Human Growth Hormone Therapy at Terminal Stage of Growth

Recombinant Human Growth Hormone After Transplantation HEIGHT VELOCITY AND HEIGHT STANDARD DEVIATION SCORES

FIGURE 16-27 Because growth often remains poor despite a functioning renal graft, a large multicenter controlled study was initiated to evaluate the effectiveness of recombinant human growth hormone in stimulating growth in children with a kidney allograft. In all three groups a significantly different growth velocity and change in height SDS occurred during the first year of treatment with gro...

Advances in Recombinant Human Growth Hormone Replacement Therapy in Adults

Acquired growth hormone (GH) deficiency results from the destruction of normal pituitary and/or hypothalamic tissue, usually from a tumor or secondary to surgical and/or radiation therapy. Diagnostic criteria and clinical sequelae of GH deficiency, although well established in children, are currently areas of active investigation in the adult. It is now apparent that acquired GH deficiency is a...

Purification of Large Quantities of Biologically Active Recombinant Human Growth Hormone

Production and purification of human growth hormone using a simple method was studied in two recombinantEscherichia coli, D7-5 and C27-2 strains. The r-hGH was expressed in the form of inclusion body in a batchfermentation process and purified to 99% purity using a procedure based on acid precipitation of the hostderived proteins and other impurities. The effect of the pH and ...

Effects of recombinant human growth hormone therapy on bone mineral density in adults with growth hormone deficiency: a meta-analysis.

OBJECTIVE GH deficiency is associated with decreased bone mineral density (BMD) and increased fracture risk. Because the effects of recombinant human GH (rhGH) therapy on BMD and bone mineral content have not been systematically investigated, we conducted a meta-analysis of pertinent studies. DESIGN A thorough search of the literature (MEDLINE, EMBASE, and the Cochrane Register) was performed...

Evaluation of Heat Induction Strategy for Recombinant Human Growth Hormone Expression in Fed-Batch Fermentation